The Darien gap, it is located on the border of Colombia and Panama in which is found an extensive forest in the Darien Region. This analysis document comes up from the “Misión Empresarial” that took place in February of 2018, During this article, the advantages and disadvantages generated by the Pan-American way will be identified, the step of which will review the factors and possible variables that have not allowed land transit at the bilateral and multilateral levels, such infrastructure would connect the Pan-American highway throughout the Americas, in turn, will present the main reasons that interrupt international trade taking into account environmental, political, social, security and risk, in order to assess the feasibility of opening this border via land under the current context.